Anillin: a pivotal organizer of the cytokinetic machinery
نویسندگان
چکیده
منابع مشابه
Anillin: a pivotal organizer of the cytokinetic machinery.
Cytokinesis is a dynamic and plastic process involving the co-ordinated regulation of many components. Accordingly, many proteins, including the putative scaffold protein anillin, localize to the cleavage furrow and are required for cytokinesis, but how they function together is poorly understood. Anillin can bind to numerous other furrow components, including F-actin, septins and myosin II, bu...
متن کاملAnillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast
In fission yeast cells cortical nodes containing the protein Blt1p and several kinases appear early in G2, mature into cytokinetic nodes by adding anillin Mid1p, myosin-II, formin Cdc12p, and other proteins, and condense into a contractile ring by movements that depend on actin and myosin-II. Previous studies concluded that cells without Mid1p lack cytokinetic nodes and assemble rings unreliabl...
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The cytokinetic furrow is organized by the RhoA GTPase, which recruits actin and myosin II to the furrow and drives contractility. Here, we show that the RhoA GTPase-activting protein (GAP) p190RhoGAP-A (also known as ARHGAP35) has a role in cytokinesis and is involved in regulating levels of RhoA-GTP and contractility. Cells depleted of p190RhoGAP-A accumulate high levels of RhoA-GTP and marke...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2008
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0360439